1. Jan 01, 2020

Changes in Corneal and Lens Density in Pediatric Patients With Celiac Disease

A new study assessed early changes in corneal and lens density in pediatric patients with celiac disease.

The observational and prospective study included 100 patients with and without celiac disease. Corneal and lens density were assessed with Pentacam HR (Oculus Optikgeräte GmbH, Wetzlar, Germany).

Results showed that mean lens and corneal density outcomes in all zones did not differ between groups (P > .05 for each). Maximum lens density was significantly higher in the celiac disease group than control group (P = .028). Mean corneal density at the peripheral cornea was significantly higher in female patients than male patients in the celiac disease group (P < .05 for each). Adhering to a gluten-free diet, body mass index, and histological classification of celiac disease had no significant effect on lens and corneal density in patients with celiac disease (P > .05 for each).

Overall, having celiac disease did not affect mean corneal and lens density. However, higher maximum lens density in patients with celiac disease may suggest early stages of ocular involvement.

Reference:

Ozates S, Doguizi S, Ozbay Hosnut F, Sahin G, Sekeroglu MA, Yilmazbas P. Assessment of corneal and lens density in children with celiac disease. J Pediatr Ophthalmol Strabismus. 2019;56(6):402-406. doi: 10.3928/01913913-20191009-01.