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Retina

OCT shows potential in the early detection of Alzheimer’s disease

Posted on February 1, 2021

Optical coherence tomography (OCT) may aid in the early detection of Alzheimer’s disease (AD), according to a study that examined the relationship between retinal nerve fiber layer thickness and AD.

In this observational, analytical, cross‐sectional study, 32 patients (64 patients) with AD or mild cognitive impairment and a group of healthy controls underwent an ophthalmological and a comprehensive neuropsychological evaluation.

Researchers found that in the superior and temporal quadrants of the retina, there was a significant linear trend towards a thinning of the retinal nerve fiber layer as the degree of cognitive deterioration increased. A significant correlation was also found between the mean thickness of the retinal nerve fiber layer of the left temporal quadrant and occipital white matter lesions.

Reference
Carazo-Barrios L, Archidona-Arranz A, Claros-Ruiz A, et al. Correlation between retinal nerve fibre layer thickness and white matter lesions in Alzheimer’s disease. Int J Geriatr Psychiatry. 2021; https://doi.org/10.1002/gps.5496.

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