Key Takeaways
- Manual resegmentation improved OCTA sensitivity for detecting choroidal neovascularization from 68% to 88% while maintaining 100% specificity.
- Combining SD-OCT with manually resegmented OCTA achieved the highest diagnostic accuracy, outperforming the combination of SD-OCT and fluorescein angiography.
Manual resegmentation of optical coherence tomography angiography (OCTA) images improved detection of choroidal neovascularization (CNV) in neovascular age-related macular degeneration (nAMD), increasing diagnostic sensitivity to a level comparable with standard imaging modalities, according to a study.
Researchers compared multimodal imaging, including fluorescein angiography (FA), spectral-domain optical coherence tomography (SD-OCT), and OCTA, in patients with nAMD. In patients with unilateral disease, the fellow eye with dry AMD (n = 39) was also evaluated to assess diagnostic sensitivity and specificity. OCTA images with inaccurate automated segmentation caused by retinal distortion underwent manual resegmentation.
Spectral-domain optical coherence tomography demonstrated 86% sensitivity and 100% specificity for diagnosing nAMD, while FA achieved 82% sensitivity and 100% specificity. Automatically segmented OCTA had lower sensitivity at 68%, although specificity remained 100%. After manual resegmentation, OCTA sensitivity increased to 88% while maintaining 100% specificity.
Diagnostic accuracy was highest when SD-OCT was paired with manually resegmented OCTA, compared with the combination of SD-OCT and FA, though both methods showed strong performance.
Reference
Asanad S, Thomspon J. Clinical Value of Optical Coherence Tomography Angiography in Neovascular Age-Related Macular Degeneration. J Clin Med. 2026 Jun 27;15(13):5013. doi: 10.3390/jcm15135013. PMID: 42452475.
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