Retinal disease severity, central nervous system disease may be correlated

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More than 70% of patients with incontinentia pigmenti (IP) had retinal disease on fluorescein angiography (FA), according to a poster presented at AAO 2020 Virtual.

Researchers conducted a consecutive case series on patients with IP who had records of FA and a cross-sectional study of images and chart reviews to determine the presence of CNS disease. FA images were assessed by 2 masked graders for severity.

Retinal disease was found on 74% of FA images. The cross-sectional study found that 19% of patients had CNS disease. Patients with CNS disease had higher retinal disease severity. Retinal involvement was found in all patients with CNS disease and 23% of patients with retinal disease had known CNS disease.

Danford I, et al. Prevalence of Retinal Disease and Associated CNS Pathology in Incontinentia Pigmenti. Presented at: AAO 2020 Virtual

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