Thyroid Eye Disease

TED biomarkers provide potential information for therapeutic targets

Posted on

A regulatory pathway of biomarkers for thyroid eye disease (TED) was constructed by researchers to help diagnose TED and understand orbital involvement, according to a study. The pathway is made up of 310 connected components and 1134 interactions.

Gene biomarkers from published literature and computationally predicted from microarray gene expression data were combined in this data-driven approach.

Overall, 22 gene biomarkers—18 semi-automatically curated from the literature and 4 predicted using data-driven approaches, were found to be involved in the pathogenesis of TED. These biomarkers may provide information for targeted therapies.

“This constructed pathway can be further utilized for disease dynamics and simulation studies,” the authors concluded.

Zou H, Xu W, Wang. Y, et al. A data-driven approach for the discovery of biomarkers associated with thyroid eye disease. BMC Ophthalmol. 2021; DOI: https://doi.org/10.1186/s12886-021-01903-9

Related Articles
Lasting quality of life improvements seen after orbital decompression in patients with TED
Jul 07, 2021
Horizon Therapeutics to resupply market with Tepezza for the treatment of thyroid eye disease (TED) beginning in April
Apr 04, 2021
Positive Phase 2a Study Results Announced for Thyroid Eye Disease Treatment
Aug 04, 2020