Higher concentration of HA artificial tears shows superior results in dry eye treatment with IPL therapy

Both 0.10% and 0.15% hyaluronic acid (HA)-containing artificial tears, when used in combination with intense pulsed light (IPL) therapy, are effective in treating dry eye disease (DED), with the higher concentration showing slightly better improvement in tear stability according to a study.

The study included 42 eyes treated with 0.10% HA-containing artificial tears and 40 eyes in the 0.15% HA group. Key outcomes measured included non-invasive tear break-up time (NITBUT), Schirmer II test results, ocular surface staining, and DED-related symptoms.

At the 3-month follow-up, the 0.15% HA group showed significantly better improvement in NITBUT (P = 0.023) and recovery (P = 0.039) compared to the 0.10% HA group. In addition, multiple DED-related symptoms were associated with a lack of symptom improvement in both groups (P < 0.05). A low pre-treatment NITBUT was marginally linked to no symptom improvement in the 0.10% HA group (P = 0.047).

Reference
Lee CY, Yang SF, Chen YC, et al. The Usage of Different Hyaluronic-Acid-Containing Artificial Tears and the Treatment Outcome of Intense Pulsed Light Therapy for Dry Eye Disease: A Retrospective Cohort Study. Diagnostics (Basel). 2024;14(16):1796. doi: 10.3390/diagnostics14161796. PMID: 39202284; PMCID: PMC11354216.