Outer retinal tubulation linked to slower vision loss in geographic atrophy

A recent post hoc analysis of the phase 3 OAKS and DERBY trials suggests that outer retinal tubulation (ORT) may be associated with a slower decline in visual acuity in patients with geographic atrophy (GA).

The study examined 300 eyes randomized to sham treatment, comparing best-corrected visual acuity outcomes over 24 months in eyes with and without ORT at baseline. Among the cohort, 32% of eyes exhibited ORT at the start of the study.

Eyes with ORT experienced, on average, a loss of 5.5 fewer Early Treatment Diabetic Retinopathy Study letters than those without ORT.

Reference
Hatcher KA, Shah BK, Yu S, et al. Outer Retinal Tubulation and Vision in Geographic Atrophy: A Natural History Analysis From the Phase 3 OAKS and DERBY Trials. Ophthalmic Surg Lasers Imaging Retina. 2025;doi: 10.3928/23258160-20250108-02. Epub ahead of print. PMID: 39918755.

This content is independent editorial sponsored by Astellas. Astellas had no input in the development of this content.