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Cornea and External Disease

Optical densitometry shows promise as diagnostic tool in keratoconus

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Optical densitometry shows significant correlations with both biomechanical and morphological parameters in keratoconus, indicating its potential as a valuable diagnostic tool for assessing the progression and treatment efficacy of the disease, according to a study.

In this cross-sectional study, 436 eyes from 295 patients with KC were analyzed. Researchers measured corneal optical densitometry along with morphological and biomechanical parameters.

The study found a positive correlation between optical densitometry of various corneal layers—anterior (0-2 mm and 2-6 mm), central (0-2 mm), posterior (2-6 mm), and total (2-6 mm)—and SPA1, except for a negative correlation in the posterior layer (0-2 mm). In addition, the optical densitometry of the anterior layers (2-6 mm, 6-10 mm) and the central layer (6-10 mm) negatively affected AL1, while the posterior layer (0-2 mm) had a positive effect.

Optical densitometry of the anterior, central, and posterior layers (0-2 mm and 2-6 mm) positively influenced the morphological parameters K1F, K2F, KmF, and the absolute values of K1B, K2B, and KmB. Optical densitometry of the center (0-2 mm) and posterior (2-6 mm) layers negatively influenced TCT.

The study also found that optical densitometry of the anterior (0-2 mm and 2-6 mm), central (0-2 mm), posterior (2-6 mm), and total (2-6 mm) layers correlated positively with ACE and PCE, whereas the posterior layer (0-2 mm) correlated negatively.

Reference
Yang M, Tian H, Xue C, Li J. Diagnostic value of corneal optical densitometry in keratoconus. Int Ophthalmol. 2024;44(1):294. doi: 10.1007/s10792-024-03212-8. PMID: 38943020.

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